Intensity Correction Method Customized for Multi-animal Abdominal MR Imaging with 3T Clinical Scanner and Multi-Array Coil
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概要
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Purpose: Simultaneous magnetic resonance (MR) imaging of multiple small animals in a single session increases throughput of preclinical imaging experiments. Such imaging using a 3-tesla clinical scanner with multi-array coil requires correction of intensity variation caused by the inhomogeneous sensitivity profile of the coil. We explored a method for correcting intensity that we customized for multi-animal MR imaging, especially abdominal imaging. Method: Our institutional committee for animal experimentation approved the protocol. We acquired high resolution T1-, T2-, and T2*-weighted images and low resolution proton density-weighted images (PDWIs) of 4 rat abdomens simultaneously using a 3T clinical scanner and custom-made multi-array coil. For comparison, we also acquired T1-, T2-, and T2*-weighted volume coil images in the same rats in 4 separate sessions. We used software created in-house to correct intensity variation. We applied thresholding to the PDWIs to produce binary images that displayed only a signal-producing area, calculated multi-array coil sensitivity maps by dividing low-pass filtered PDWIs by low-pass filtered binary images pixel by pixel, and divided uncorrected T1-, T2-, or T2*-weighted images by those maps to obtain intensity-corrected images. We compared tissue contrast among the liver, spinal canal, and muscle between intensity-corrected multi-array coil images and volume coil images. Results: Our intensity correction method performed well for all pulse sequences studied and corrected variation in original multi-array coil images without deteriorating the throughput of animal experiments. Tissue contrasts were comparable between intensity-corrected multi-array coil images and volume coil images. Conclusion: Our intensity correction method customized for multi-animal abdominal MR imaging using a 3T clinical scanner and dedicated multi-array coil could facilitate image interpretation.
著者
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MORIYAMA Noriyuki
Research Center for Cancer Prevention and Screening, National Cancer Center
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Moriyama Noriyuki
Research Center For Cancer Prevention And Screening National Cancer Center
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Yamaguchi Masayuki
Functional Imaging Division National Cancer Hospital East
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Niitsu Mamoru
Department Of Radiological Science Faculty Of Health Sciences Tokyo Metropolitan University
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Fujii Hirofumi
Functional Imaging Division National Cancer Hospital East
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Furuta Toshihiro
Functional Imaging Division Research Center For Innovative Oncology National Cancer Center Hospital East
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Mitsuda Minoru
Functional Imaging Division Research Center For Innovative Oncology National Cancer Center Hospital East
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FUJII Hirofumi
Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East
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SEKINE Norio
Graduate School of Human Health Sciences, Tokyo Metropolitan University
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NAKAGAMI Ryutaro
Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East
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