Recent structural studies on Dom34/aPelota and Hbs1/aEF1α: important factors for solving general problems of ribosomal stall in translation

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概要

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• In the translation process, translating ribosomes usually move on an mRNA until they reach the stop codon. However, when ribosomes translate an aberrant mRNA, they stall. Then, ribosomes are rescued from the aberrant mRNA, and the aberrant mRNA is subsequently degraded. In eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation. In archaea, aPelota and aEF1α, homologous to Pelota and Hbs1, respectively, are considered to be involved in that process. In recent years, great progress has been made in determining structures of Dom34/aPelota and Hbs1/aEF1α. In this review, we focus on the functional roles of Dom34/aPelota and Hbs1/aEF1α in ribosome rescue, based on recent structural studies of them. We will also present questions to be answered by future work.

著者

• Nureki Osamu

  Department Of Basic Medical Science Tokyo University

• Kobayashi Kan

  Department Of Anatomy School Of Dentistry At Niigata The Nippon Dental University

• Ishitani Ryuichiro

  Department Of Basic Medical Sciences Institute Of Medical Science The University Of Tokyo

• Ishitani Ryuichiro

  Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo

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