The Efficacy and Safety of Telaprevir-based Regimens for Treating Chronic Hepatitis C Virus Genotype 1 Infection: A Meta-analysis of Randomized Trials
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概要
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Objective Previous studies have reported that telaprevir is effective for treating chronic hepatitis C virus (HCV) genotype 1 infection; however, the efficacy and safety of telaprevir-based regimens remain uncertain. Methods To assess the efficacy and safety of telaprevir in patients with chronic HCV genotype 1 infection, we conducted a meta-analysis of all available randomized controlled trials (RCT) comparing the efficacy and safety of the addition of telaprevir to a standard regimen (combination of telaprevir with peginterferon and ribavirin, TPR group) with the standard regimen alone (peginterferon and ribavirin, PR group). Results Ultimately, six RCTs involving a total of 2,759 patients with chronic HCV genotype 1 infection were included in this meta-analysis. The outcomes showed that the sustained virologic response (SVR) rate was significantly higher in the TPR group (1,284/1,932, 66.5%) than in the PR group (296/827, 35.8%) with a pooled odds ratio (OR) [3.81, 95% confidence interval (CI) 2.43-5.96, p<0.001]. The results also showed that the relapse rate was significantly lower in the TPR group (190/1,484, 12.8%) than in the PR group (140/425, 32.9%) with a pooled risk ratio (RR) (0.40; 95% CI 0.24-0.66, p<0.001). However, there was an increased risk of serious adverse events in the TPR group (RR=1.45, 95% CI 1.12-1.87, p=0.005). Conclusion Telaprevir-based regimens can significantly increase the SVR rate and reduce the relapse rate in patients with chronic HCV genotype 1 infection. However, the safety of telaprevir-based regimens still requires further study.
著者
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Liang Hai
Department of Infectious Diseases, the First Affiliated Hospital of Xinxiang Medical College, China
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Yang Daokun
Department of Infectious Diseases, the First Affiliated Hospital of Xinxiang Medical College, China
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Li Duan
The State Key Discipline and Center for Infectious Diseases, Tangdu Hospital of the Fourth Military Medical University, China
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Wei Xin
The State Key Discipline and Center for Infectious Diseases, Tangdu Hospital of the Fourth Military Medical University, China
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Ma Li
The State Key Discipline and Center for Infectious Diseases, Tangdu Hospital of the Fourth Military Medical University, China
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Jia Zhansheng
The State Key Discipline and Center for Infectious Diseases, Tangdu Hospital of the Fourth Military Medical University, China