Epidemiologic Methods of Assessing Asthma and Wheezing Episodes in Longitudinal Studies: Measures of Change and Stability

スポンサーリンク

概要

• 論文の詳細を見る

• Background: In settings in which diseases wax and wane, there is a need to measure disease dynamics in longitudinal studies. Traditional measures of disease occurrence (eg, cumulative incidence) do not address change or stability or are limited to stable cohorts (eg, incidence) and may thus lead to erroneous conclusions. To illustrate how different measures can be used to detect disease dynamics, we investigated sex differences in the occurrence of asthma and wheezing, using a population-based study cohort that covered the first 18 years of life.<BR>Methods: In the Isle of Wight birth cohort (n = 1456), prevalence, incidence, cumulative incidence, positive and negative transitions, and remission were determined at ages 1 or 2, 4, 10, and 18 years. Latent transition analysis was used to simultaneously identify classes of asthma and wheezing (related phenotypes) and characterize transition probabilities over time. Trajectory analysis was used to characterize the natural history of asthma and wheezing.<BR>Results: Regarding time-specific changes, positive and negative transition probabilities were more informative than other measures of associations because they revealed a sex switchover in asthma prevalence (P < 0.05). Transition probabilities were able to identify the origin of a sex-specific dynamic; in particular, prior wheezing transitioned to asthma at age 18 years among girls but not among boys. In comparison with latent transition analysis, trajectory analysis did not directly identify a switchover in prevalence among boys and girls.<BR>Conclusions: In longitudinal analyses, transition analyses that impose minimal restrictions on data are needed in order to produce appropriate information on disease dynamics.

著者

• ZHANG Hongmei

  Department of Applied Chemistry, Fushun Petroleum Institute

• Soto-Ramírez Nelís

  Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis

• Karmaus Wilfried

  Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis

• Ziyab Ali

  Department of Epidemiology and Biostatistics, University of South Carolina

• Kurukulaaratchy Ramesh

  David Hide Asthma and Allergy Research Centre, Isle of Wight, and University of Southampton

• Ewart Susan

  Michigan State University

• Arshad Syed

  David Hide Asthma and Allergy Research Centre, Isle of Wight, and University of Southampton

関連論文

• Preparation and Properties of Conducting Polymer Blends of Polyaniline in Poly(vinyl formal) or Poly(methacrylic acid)
• Dendritic cells pulsed with α-fetoprotein and mutant P53 fused gene induce bi-targeted cytotoxic T lymphocyte response against hepatic carcinoma
• Preparation of Natural Borneol/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex and Its Effect on the Absorption of Tetramethylpyrazine Phosphate in Mouse
• Epidemiologic Methods of Assessing Asthma and Wheezing Episodes in Longitudinal Studies: Measures of Change and Stability

スポンサーリンク