A Rat Model of Intracerebral Hemorrhage Permitting Hematoma Aspiration plus Intralesional Injection
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概要
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A combination of hematoma aspiration and local delivery of chemicals may be more effective than either therapy in intracerebral hemorrhage (ICH). The aim of the present study was to develop a rat model of hematoma aspiration plus intralesional injection after ICH. ICH was induced in adult Sprague-Dawley rats by an intrastriatal injection of bacterial collagenase IV. Hematoma aspiration was performed 3.5 h after ICH onset. Following aspiration, normal saline was injected into the lesion cavity. Hematoma aspiration with or without subsequent saline injection significantly reduced the hematoma volume, lesion volume, and perihematomal neutrophil infiltration. Hematoma aspiration plus subsequent intralesional injection is simple, feasible, and safe. This ICH model can be used to assess the effectiveness of hematoma removal plus local delivery of chemicals.
著者
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SO Kwok-Fai
State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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CHEUNG Raymond
Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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LIANG Yu-Xiang
State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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LIU Ling-Guang
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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ELLIS-BEHNKE Rutledge
Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University, Heidelberg, Germany
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SANG Yan-Hua
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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WU Wu-Tian
Research Centre of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
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ELLIS-BEHNKE Rutledge
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong
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LIU Ling-Guang
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
関連論文
- A Rat Model of Intracerebral Hemorrhage Permitting Hematoma Aspiration plus Intralesional Injection
- A Rat Model of Intracerebral Hemorrhage Permitting Hematoma Aspiration plus Intralesional Injection