Neu2000 Potentiates a Kainate Response in Mouse Cortical Neurons

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Neu2000, acting as an antioxidant with N-methyl-<span style="font-variant: small-caps;">d</span>-aspartate–receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 non-competitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.