Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells

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概要

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• Prostaglandin E2 (PGE2) was shown to induce neuronal death in the CNS. To characterize the neurotoxicity of PGE2 and E-prostanoid receptors (EP) in motor neurons, we investigated PGE2-induced cell death and the type(s) of EP responsible for mediating it in NSC-34, a motor neuron-like cell line. Immunoblotting studies showed that EP2 and EP3 were dominantly expressed in NSC-34 cells and motor neurons in mice. Exposure to PGE2 and butaprost, an EP2 agonist, but not sulprostone, an EP1/3 agonist, resulted in decreased viability of these cells. These results suggest that PGE2 induces cell death by activation of EP2 in NSC-34 cells.

著者

• Ito Yoshihisa

  Laboratory Of Pharmacology School Of Pharmacy Nihon University

• MIYAGISHI Hiroko

  Laboratory of Pharmacology, School of Pharmacy, Nihon University

• Ishige Kumiko

  Laboratory Of Pharmacology School Of Pharmacy Nihon University

• Osada Nobuhiro

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

• Kusama-Eguchi Kuniko

  Laboratory of Biochemistry, School of Pharmacy, Nihon University, Japan

• Kosuge Yasuhiro

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

• Kosuge Yasuhiro

  Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University

• Yoneoka Yuki

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

• Ozone Maiko

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

• Endo Manami

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

• Miyagishi Hiroko

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

• Ishige Kumiko

  Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

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