Small cell carcinoma of the endometrium treated effectively with paclitaxel and carboplatin

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Small cell carcinoma of the endometrium is a rare histological type and has a poor clinical course. This is a case report of advanced stage of small cell carcinoma of the uterine corpus, showing a remarkable response to chemotherapy. A 73-year-woman with inoperable stage IIIA corpus cancer histologically displayed an endometrial small-cell carcinoma. Immuno-histochemically, the tumor cells were positive for synaptophysin and neuron-specific enolase, but were negative for the chromogranin. She was treated with chemotherapy of paclitaxel and carboplatin (TC) regimen. After 5 courses of TC regimen, the tumor shrank remarkably and in surgery, hysterectomy and salpingo-oophorectomy could be performed optimally. After an additional 2 courses of TC regimen, the patient was discharged and no recurrence was shown for 3 years. In our case, the TC regimen seemed effective for small cell carcinoma of the endometrium, and it could be the first choice for chemotherapy in such cases. [Adv Obstet Gynecol, 64(4) : 495-499, 2012 (H24.11)]