Distribution and Dynamics of Intracellular ATP Level, and their Regulation

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概要

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• ATP is indispensable for all living organisms. Despite its importance, however, distribution and dynamics of ATP level inside living cells still remained unclear. We have developed FRET-based ATP biosensors, "ATeam" and "GO-ATeam", which enabled us to visualize intracellular ATP level. Using these biosensors, we have successfully evaluated the effect of IF1 protein and Ca2+ on regulation of ATP level. Also, we found that replication of hepatitis C virus genome resulted in the declination of cytosolic ATP level of host cells and the formation of putative virus replication sites with high ATP levels.

著者

• 今村 博臣

  京都大学白眉センター

• 安東 友美

  国立感染症研究所ウイルス第二部

• 藤川 誠

  東京理科大学薬学部

関連論文

• Distribution and Dynamics of Intracellular ATP Level, and their Regulation
• 細胞内ATPの分布とダイナミクス, その制御

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