Unsuccessful Cyclosporine Plus Prednisolone Therapy for Autoimmune Meningoencephalitis in Three Dogs
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概要
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A 4-year-old female Maltese (case 1), a 9-year-old castrated male Shih-Tzu (case 2) and 2-year-old female Pomeranian (case 3) were presented because of neurological signs such as head tilt, ataxia, circling and paresis. Three cases were tentatively diagnosed to meningoencephalitis of unknown etiology based on computed tomography scan and cerebrospinal fluid analysis. All patients were managed with cyclosporine plus prednisolone therapy. The survival times of three patients were 170, 70 and 21 days, respectively. After cases expired, we performed necropsy and histopathological examination for definitive diagnosis. Based on the necropsy, histopathological and immunohistochemical examinations, case 1, 2 and 3 were definitely diagnosed to necrotizing meningoencephalitis, necrotizing leukoencephlaitis and granulomatous meningoencephalitis, respectively. This case report demonstrated that the clinical findings, brain CT characteristics, histopathological and immunohistochemical features of NME, NLE and GME in dogs and discussed about the reason of relatively short survival times under cyclosporine plus prednisolone therapy.
著者
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KANG Byeong-Teck
Laboratory of Veterinary Dermatology and Neurology, College of Veterinary Medicine, Chungbuk National University
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JUNG Dong-In
Research Institute of Life Sciences, Gyeongsang National University
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SUR Jung-Hyang
Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
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KIM Na-Hyun
Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Korea
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CHO Kyu-Woan
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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KANG Byeong-Teck
Laboratory of Veterinary Dermatology and Neurology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361–763, South Korea
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LEE Hee-Chun
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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HA Jeongim
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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JUNG Hae-Won
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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JEON Joon-Hyeok
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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MOON Jong-Hyun
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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LEE Jae-Hoon
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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KIM Na-Hyun
Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 143–701, South Korea
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JUNG Dong-In
Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University, Jinju 660–701, South Korea
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SUR Jung-Hyang
Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 143–701, South Korea
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