The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in Rat Pancreas

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概要

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• Free fatty acids play an important role in regulating animal insulin secretion response. Acute elevated free fatty acids increased animal insulin secretion and glucose-stimulated insulin secretion. In the present study, we perfused rat pancreas to explore the effect of unsaturated fatty acids on insulin secretion. The results showed that linoleic acid, γ-linolenic acid, and arachidonic acid significantly stimulated insulin secretion. Glucose (10 mM) alone induced a biphasic insulin secretion response. The peak effluent insulin concentrations over the baseline were 444% and 800% increase in the first and second insulin secretion phase, respectively. By comparing the percentage increases, arachidonic acid, γ-linolenic acid, or linoleic acid increased glucose-induced insulin release by 555% and 934%, 522% and 995% and 463% and 1,105% in the first and second insulin secretion phase, respectively. However, the percentage increases of insulin secretion were significantly decreased to 402% and 564% in the first and second phase in the rat fed with high-fat diet for 13 weeks. Linoleic acid alone stimulated a 391% increase of the baseline in the peak insulin concentration in the rat fed with a normal diet. The peak insulin concentration was significantly decreased to183% in the rats fed with a long-term high-fat diet. All the results suggested that unsaturated fatty acids stimulated insulin secretion and additively increased glucose-induced insulin secretion in the perfused rat pancreas. However, the rat fed with a high fat diet decreased linoleic acid-induced insulin secretion response.

著者

• Yang Chi

  Department Of Physics National Chung Cheng University

• YANG Chi

  Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, No.250, Kuo Kuang Road, Taichung City, Taiwan 402, R.O.C.

• LAI Min-Chuan

  Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, No.250, Kuo Kuang Road, Taichung City, Taiwan 402, R.O.C.

• TENG Tzu-Hua

  Food and Drug Administration, Department of Health, Executive Yuan No.161–2, Kunyang St., Nangang Dist., Taipei City 115 Taiwan, R.O.C.

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