Molecular Characterization and Tissue Distribution of Feline Retinol-Binding Protein 4

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概要

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• Retinol-binding protein 4 (RBP4) is a specific transporter of retinol and was recently identified as an adipokine potentially involved in type 2 diabetes in humans and rodents. However, the function and structure of feline RBP4 have not been reported. In this study, we describe the molecular cloning and expression analysis of feline RBP4. The complete feline RBP4 cDNA encodes a precursor protein comprising an 18 amino acid signal peptide and a 183 amino acid mature protein. Feline RBP4 was mapped to chromosome D2. Mature feline RBP4 is 83–94% homologous to the RBPs of humans, cows and rodents. RT-PCR analysis revealed feline RBP4 expression in liver and adipose tissues.

著者

• SOETA Satoshi

  Laboratory of Veterinary Anatomy, Nippon Veterinary and Life Science University

• Sasaki Noriyasu

  Laboratory Of Biochemistry Department Of Biomedical Sciences Graduate School Of Veterinary Medicine

• SASAKI Noriyasu

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180–8602, Japan

• ISHIBASHI Miwa

  Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180–8602, Japan

• SOETA Satoshi

  Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180–8602, Japan

関連論文

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• Key Role of Glycogen Storage in High K+-Induced Contraction of the Smooth Muscles of the Bovine Trachea
• Molecular Characterization and Tissue Distribution of Feline Retinol-Binding Protein 4

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