Resveratrol Ameliorates the Oxidative Damage Induced by Arsenic Trioxide on Feline Lung
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概要
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The objective of this study was to evaluate the possible protection of resveratrol against lung injury induced by arsenic trioxide (As2O3). Twenty-four healthy Chinese Dragon-Li cats of either sex were randomly divided into four groups: control (1 ml/kg physiological saline), As2O3 (1 mg/kg), resveratrol (3 mg/kg) and resveratrol (3 mg/kg) + As2O3 (1 mg/kg). The resveratrol + As2O3 treated-group was given resveratrol 1 hr before As2O3 (1 mg/kg) administration. We found that pretreatment with resveratrol in a clinically comparable dose regimen can reversed the changes in morphological and biochemical parameters induced by As2O3 in lung. Resveratrol treatment also up-regulated the activities of antioxidant enzymes, and attenuated As2O3-induced increases in reactive oxygen species, 8-hydroxydeoxyguanosine and malondialdehyde production in lung. In addition, resveratrol attenuated the As2O3-induced reduction in the ratio of reduced glutathione to oxidized glutathione, the content of total glutathione and lung arsenic burden. These findings indicated that resveratrol can give a significant protection against As2O3-induced oxidative damage.
著者
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Gao Li
College Of Agronomy And Biotechnology China Agriculture University
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Liu Yan
College Of Chemistry And Chemical Technology Shanghai Jiao Tong University
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ZHANG Zhigang
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
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CHENG Yanyan
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
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XUE Jiangdong
College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao 028000, China
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YAO Chunyu
College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao 028000, China
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MA Dexing
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
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LIU Yan
College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao 028000, China
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