Effect of Topical Adminstration of 0.8% Nalbuphine on Cornea in Dogs after Phacoemulsification

概要

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It is suggested that topical application of opioids may provide localized analgesia without delay in corneal wound healing. This study was designed to evaluate the effect of topical application of 0.8% nalbuphine on post-operative ocular pain in dogs. Twelve eyes from 11 dogs undergoing phacoemulsification cataract surgery were divided into Nalbuphine group (n=6) and Saline group (n=6). Post-operatively, the Nalbuphine group received 0.1 ml of topical 0.8% alkalinized nalbumine (pH 5.6) every 8 hr and the Saline group received 0.1 ml of topical saline (pH 5.9) as placebo. All dogs received systemic post-operative pain managements with oral tramadol (4 mg/kg) and prednisolone (0.5 mg/kg) every 8 hr. All dogs received pre and post ophthalmic examinations. The dogs were pain scored using a pain scoring system modified from the University of Melbourne pain scale at 15, 30 and 60 min following the topical treatment on Day-1 and -2 (24 and 48 hr after the surgery). Eye blink frequency and corneal touch threshold (CTT) were recorded at the same time. There was no statistical difference in the pain score between groups. Significant decrease in CTT, blepharospasm, and eye blink frequency were observed after the topical nalbuphine treatment. It is indicated that topical application of 0.8% nalbuphine solution can produce a rapid reduction of corneal discomfort in dogs.