Cross-Reactivity of Secondary Antibodies against African Rodents and Application for Sero-Surveillance

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概要

• 論文の詳細を見る

• A total of 466 rodents were captured in the Republic of Zambia from 2006 to 2010. Based on morphological observations and phylogenetic analyses of mitochondrial gene sequences, rodents were divided into 10 groups consisting of 39 Rattus rodents, 263 multimammate rats, 18 other Murinae rodents, 95 gerbils, 11 pouched mice, 1 giant-pouched rat, 38 fat mice and 1 dormouse. Rodent antibodies except that from Rattus were examined for their cross-reactivity to commercially available antibody detection reagents. Anti-mouse immunoglobulin G (IgG) was most cross-reactive to heterologous antibodies including multimammate rat, gerbil, pouched mouse and fat mouse. Thus, anti-mouse IgG would be a useful detection tool in serological examination of the Zambian rodent population. Preliminary sero-surveillance for plague, leptospirosis and hantavirus infection was performed by ELISA.

著者

• Sawa Hirofumi

  Hokkaido Univ. Sapporo Jpn

• Takada Ayato

  Hokkaido Univ. Res. Center For Zoonosis Control Hokkaido

• YOSHIMATSU Kumiko

  Graduate School of Medicine, Hokkaido University

• ARIKAWA Jiro

  Graduate School of Medicine, Hokkaido University

• Nakamura Ichiro

  Hokkaido Univ. Res. Center For Zoonosis Control Sapporo Jpn

• ARIKAWA Jiro

  Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, Hokkaido 060–8638, Japan

• KOBAYASHI Shintaro

  Hokkaido University Research Center for Zoonosis Control, N20W10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

• ORBA Yasuko

  Hokkaido University Research Center for Zoonosis Control, N20W10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

• ISHII Akihiro

  Hokkaido University Research Center for Zoonosis Control, N20W10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

• THOMAS Yuka

  Hokkaido University Research Center for Zoonosis Control, N20W10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

• ISOZUMI Rie

  Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, Hokkaido 060–8638, Japan

• MWEENE Aaron

  School of Veterinary Medicine, University of Zambia, P. O. Box 32379, Lusaka, Zambia

• SUGIMOTO Chihiro

  Hokkaido University Research Center for Zoonosis Control, N20W10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

• YOSHIMATSU Kumiko

  Graduate School of Medicine, Hokkaido University, N15W7, Kita-ku, Sapporo, Hokkaido 060–8638, Japan

• NAKAMURA Ichiro

  Hokkaido University Research Center for Zoonosis Control, N20W10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

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