Polyglutamine tract-binding protein 1の構造生物学的研究

スポンサーリンク

概要

• 論文の詳細を見る

•   Polyglutamine tract-binding protein 1 (PQBP1) is a nuclear protein that regulates transcription and pre-mRNA splicing. In addition, the mutations in the PQBP1 gene are known to cause hereditary mental retardation. This review summarizes current knowledge about the solution structure of PQBP1. PQBP1 is an intrinsically disordered protein: its polar-rich domain and C-terminal domain are disordered under physiological conditions. PQBP1 binds to its target molecule U5-15kD via a continuous 23-residue segment of the C-terminal domain. The function of PQBP1 in the pre-mRNA splicing is also discussed.

著者

• 水口 峰之

  Faculty of Pharmaceutical Sciences, University of Toyama

• 岡澤 均

  Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University

関連論文

• Polyglutamine tract-binding protein 1の構造生物学的研究

スポンサーリンク