Myocardial Stretch in Early Systole is a Key Determinant of the Synchrony of Left Ventricular Mechanical Activity in vivo

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概要

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• Background:  Recent in-vitro observations suggest that left ventricular (LV) contraction is powered by 'stretch activation', an intrinsic mechanism by which the stretching of an activated cardiomyocyte causes delayed force redevelopment. We hypothesized that mechanical dyssynchrony is related to prolonged early systolic stretch that delays the timing of peak segmental shortening. Methods and Results: The time intervals from R wave to segmental longitudinal stretch in early systole (Tstretch) and peak shortening (Tpeak) and the respective standard deviations (σTstretch and σTpeak) were measured by speckle-tracking echocardiography in 57 patients undergoing cardiac resynchronization therapy (CRT). The percentage of time spent in shortening, normalized to Tpeak duration [corrected ΔT=(Tpeak–Tstretch)/Tpeak] correlated with LV reverse remodeling (reduction in end-systolic volume ≥15%). Of the 57 patients, 40 (70.2%) demonstrated LV reverse remodeling at an average follow-up of 263±125 days after CRT. At baseline, Tstretch and σTstretch correlated with Tpeak and σTpeak, respectively. Though there was no difference in Tstretch, Tpeak, σTstretch and σTpeak between responders and non-responders, corrected ΔT in the mid-lateral and mid-septal segments was shorter in the responders (P<0.05 for both) and the average of the 2 independently predicted LV reverse remodeling (area under the curve: 0.77, P=0.001). Conclusions: Mapping LV segmental shortening in relation to early systolic stretch may aid dyssynchrony assessment in patients undergoing CRT.

著者

• Sengupta Partho

  Division Of Cardiovascular Diseases Mayo Clinic

• Abe Haruhiko

  Division Of Cardiology University Of Occupational And Environmental Health

• Narula Jagat

  Zena And Michael A. Wiener Cardiovascular Institute And Marie-josee And Henry R. Kravis Cardiovascular Health Center Mount Sinai School Of Medicine

• Nakabo Ayumi

  Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine

• Sengupta Partho

  Division of Cardiovascular Diseases, Mayo Clinic

• Caracciolo Giuseppe

  Division of Cardiovascular Diseases, Mayo Clinic

• Goliasch Georg

  Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine

• Amaki Makoto

  Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine

• Bansal Manish

  Medanta, The Medicity

• Scott Luis

  Division of Cardiovascular Diseases, Mayo Clinic

• Lipar Luka

  Division of Cardiovascular Diseases, Mayo Clinic

• Pedrizzetti Gianni

  Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine

関連論文

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• Myocardial Stretch in Early Systole is a Key Determinant of the Synchrony of Left Ventricular Mechanical Activity in vivo
• Myocardial Stretch in Early Systole is a Key Determinant of the Synchrony of Left Ventricular Mechanical Activity in Vivo

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