Regression of Luminal Stenosis at the Site of Silent Plaque Disruption in the Era of Optimal Medical Therapy:– Low High-Density Lipoprotein Cholesterol Level Is a Potential Risk of Stenosis Progression –
スポンサーリンク
概要
- 論文の詳細を見る
Background: Plaque disruption and its healing is thought to be the major mechanism of atherosclerosis, but the contribution of silent plaque disruption to luminal stenosis progression has not been fully clarified. The aim of this study was therefore to examine the change in luminal stenosis at the site of silent plaque disruption. Methods and Results: Consecutive patients (n=36) who received coronary angiography and angioscopy that identified silent plaque disruption (baseline) and had repeated coronary angiography later (follow-up) were included for analysis. Silent plaque disruption was defined as plaque with thrombus detected in non-culprit segments. Diameter stenosis of the site was angiographically measured at baseline and at follow-up, and their difference was defined as stenosis change. Statin was used in 89% of study patients, and serum low-density lipoprotein cholesterol level was 91±21mg/dl. The diameter stenosis decreased significantly from baseline to follow-up at 12±4 months (32±14% vs. 27±14%, P<0.001), and the stenosis change was −5.6±7.9%. High-density lipoprotein cholesterol (HDL-C) was significantly associated with stenosis change (r=−0.51, P=0.001) and was the only factor significantly associated with stenosis change. Conclusions: In the era of optimal medical therapy with statin, the site of silent plaque disruption showed significant regression of luminal stenosis. Nevertheless, serum HDL-C was inversely associated with stenosis change, and its low level remained as a potential risk of luminal stenosis progression at the site of silent plaque disruption.
著者
-
Hirata Akio
Cardiovascular Division Osaka Police Hospital
-
Nemoto Takayoshi
Cardiovascular Division Osaka Police Hospital
-
Ueda Yasunori
Cardiovascular Division Osaka Police Hospital
-
Matsuo Koshi
Cardiovasucular Division, Osaka Police Hospital
-
Nishio Mayu
Cardiovascular Division Kansai Rosai Hospital
-
Kodama Kazuhisa
Cardiac Intensive Care Unit Of Osaka Police Hospital
-
Kashiwase Kazunori
Cardiovascular Division Amagasaki Central Hospital
-
Asai Mitsutoshi
Cardiovascular Division Osaka Police Hospital
-
Murakami Ayaka
Cardiovascular Division, Osaka Police Hospital
-
Matsuo Koshi
Cardiovascular Division, Osaka Police Hospital
関連論文
- Acute Coronary Syndrome : Insight From Angioscopy
- PJ-511 Superficial Fibro-Fatty Area Detected by Virtual Histology IVUS is Associated with Thrombus Detected by Angioscopy(Intravascular endoscopy/Intravascular ultrasound-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-354 Diabetes Mellitus is an Outstanding Risk Factor of Coronary Atherosclerosis Evaluated by Multi-detector Row Computed Tomography Even among Metabolic Syndrome(CT/DSA-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-318 Scoring System by Multi-slice Computed Tomography Angiography Can Determine Difficulty Level of Percutaneous Coronary Intervention of Chronic Total Occlusions(CT/DSA-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-170 Role of Coronary Calcium on Acute Coronary Syndrome-From the Viewpoints of Multidetector Computed Tomography and VH-IVUS(Atherosclerosis, clinical-8 (H) PE29,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- True Comparison of Different Stents in the Same Coronary Artery
- Qualitative and Quantitative Changes in Coronary Plaque Associated With Atorvastatin Therapy
- PJ-649 Effect of Noninvasive Positive Pressure Ventilation (NPPV) on the Clinical Course in Our Hospital(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-306 Chronic Kidney Disease may Raise the Risk for Cardiovascular Disease by Increasing Number of Yellow Plaques in a Coronary Artery(PE052,Kidney/Renal Circulation/CKD 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-135 Heterogeneity of Neointimal Coverage Can Expain Higher Risk of Late Loss and Late Stent Thrombosis of Paclitaxel-Eluting Stents : Angioscopic Observations(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual
- FRS-096 Different Contributors to Thrombus Formation Between Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents : Serial Angioscopic Observations(FRS20,Clinical Evidence of DES Era (2) (IHD),Featured Research Session (English),The 73rd Annual Scientif
- 5 Female Cardiologist should Have Specialty in Their Early Career!(How to Avoid Women Cardiologists from Quitting Their Job,Symposium 20 (SY-20) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- A large dissecting sub-epicardial hematoma and cardiac tamponade following elective percutaneous coronary intervention
- PJ-138 Process of Neointima Coverage over Sirolimus Drug-Eluting Stent and Maturation in Anti-thrombogenic Potential(Intravascular endoscopy/Intravascular ultrasound(05)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- PJ-084 Diastolic function is impaired at the noninfarcted region in patients with LV remodeling after myocardial infarction(Echo/Doppler(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-404 Resistance to Plaque Stabillzation in Patients With Diabetes Mellitus After Atorvastatin Treatment : Results From TWINS Study(Diabetes/Obesity/Metabolic syndrome(07)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- PE-270 Plaque Stabilization and Regression by Lipid Lowering Therapy in Patients With Coronary Heart Disease(Atherosclerosis, clinical(06)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-244 Ischemic Mitral Regurgitation : Long-Term Outcome in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention(Acute coronary syndrome, basic/clinical(04)(IHD),Poster Session(English),The 72nd Annual Scientific
- PE-306 Chronic Kidney Disease may Raise the Risk for Cardiovascular Disease by Increasing Number of Yellow Plaques in a Coronary Artery(PE052,Kidney/Renal Circulation/CKD 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-135 Heterogeneity of Neointimal Coverage Can Expain Higher Risk of Late Loss and Late Stent Thrombosis of Paclitaxel-Eluting Stents : Angioscopic Observations(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual
- FRS-096 Different Contributors to Thrombus Formation Between Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents : Serial Angioscopic Observations(FRS20,Clinical Evidence of DES Era (2) (IHD),Featured Research Session (English),The 73rd Annual Scientif
- 6 Contribution of MDCT/SPECT Fusion Image to Decide Therapeutic Strategy(A New Horizon of Cardiac CT-Beyond Lumen Visualization-,Symposium 13 (SY-13) (IHD),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-250 A Novel Role of Histamine H2 Receptors in the Pathophysiology of Canine Heart Failure Induced by Sustained Rapid Pacing(Heart failure, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-138 Process of Neointima Coverage over Sirolimus Drug-Eluting Stent and Maturation in Anti-thrombogenic Potential(Intravascular endoscopy/Intravascular ultrasound(05)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- PE-244 Ischemic Mitral Regurgitation : Long-Term Outcome in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention(Acute coronary syndrome, basic/clinical(04)(IHD),Poster Session(English),The 72nd Annual Scientific
- OE-045 Analysis on Risk of Thrombosis at Coronary Plaque : An Angioscopic Study(Atherosclerosis, clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 2 A Role of Coronary Angioscopy to Predict Thrombotic Event(The pathogenesis and preventive strategy for DES failure : Evaluation by invasive coronary imaging modalities,Roundtable Discussion 2 (RT-02) (I),Special Program,The 72nd Annual Scientific Meetin
- PE-306 Chronic Kidney Disease may Raise the Risk for Cardiovascular Disease by Increasing Number of Yellow Plaques in a Coronary Artery(PE052,Kidney/Renal Circulation/CKD 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-135 Heterogeneity of Neointimal Coverage Can Expain Higher Risk of Late Loss and Late Stent Thrombosis of Paclitaxel-Eluting Stents : Angioscopic Observations(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual
- FRS-096 Different Contributors to Thrombus Formation Between Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents : Serial Angioscopic Observations(FRS20,Clinical Evidence of DES Era (2) (IHD),Featured Research Session (English),The 73rd Annual Scientif
- PJ-138 Process of Neointima Coverage over Sirolimus Drug-Eluting Stent and Maturation in Anti-thrombogenic Potential(Intravascular endoscopy/Intravascular ultrasound(05)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- PE-244 Ischemic Mitral Regurgitation : Long-Term Outcome in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention(Acute coronary syndrome, basic/clinical(04)(IHD),Poster Session(English),The 72nd Annual Scientific
- 2 A Role of Coronary Angioscopy to Predict Thrombotic Event(The pathogenesis and preventive strategy for DES failure : Evaluation by invasive coronary imaging modalities,Roundtable Discussion 2 (RT-02) (I),Special Program,The 72nd Annual Scientific Meetin
- 1 Impact of Ischemic Mitral Regurgitation on Long-term Mortality in Patients with ST-elevated Acute Myocardial Infarction(Symposium 9 (SY-09) (M) New Insight for Treatment of Ischemic Mitral Regurgitation,Special Program,The 72nd Annual Scientific Meeting
- 2 Dual Anti-platelet Therapy is Important to Prevent Thrombosis of Drug-eluting Stent Until Neointima Formation(Symposium 1 (SY-01) (IHD) Re-Evaluation of Drug Therapy in the DES Era,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circu
- PJ-752 Process of Neointima Coverage Over Sirolimus Drug-Eluting Stent And Maturation In Anti-thrombogenic Potential(Coronary revascularization, PCI-21, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-739 Angioscopic Evaluation of Sirolimus Drug-eluting Stent At 12 Months After Implantation(Coronary revascularization, PCI-20, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-413 Long-term Effect of Standard Right Atrial Ablation for Atrioventricular Nodal Reentry with Earliest Activation in the Coronary Sinus(Arrhythmia, therapy-22, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-353 Prevalence of Coronary Plaque in Asymptomatic Volunteers with Metabolic Syndrome(CT/DSA-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-180 Impact of Ischemic Mitral Regurgitation on Long-term Mortality in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-306 Chronic Kidney Disease may Raise the Risk for Cardiovascular Disease by Increasing Number of Yellow Plaques in a Coronary Artery(PE052,Kidney/Renal Circulation/CKD 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-135 Heterogeneity of Neointimal Coverage Can Expain Higher Risk of Late Loss and Late Stent Thrombosis of Paclitaxel-Eluting Stents : Angioscopic Observations(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual
- FRS-096 Different Contributors to Thrombus Formation Between Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents : Serial Angioscopic Observations(FRS20,Clinical Evidence of DES Era (2) (IHD),Featured Research Session (English),The 73rd Annual Scientif
- PJ-138 Process of Neointima Coverage over Sirolimus Drug-Eluting Stent and Maturation in Anti-thrombogenic Potential(Intravascular endoscopy/Intravascular ultrasound(05)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- PE-244 Ischemic Mitral Regurgitation : Long-Term Outcome in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention(Acute coronary syndrome, basic/clinical(04)(IHD),Poster Session(English),The 72nd Annual Scientific
- 2 A Role of Coronary Angioscopy to Predict Thrombotic Event(The pathogenesis and preventive strategy for DES failure : Evaluation by invasive coronary imaging modalities,Roundtable Discussion 2 (RT-02) (I),Special Program,The 72nd Annual Scientific Meetin
- 1 Impact of Ischemic Mitral Regurgitation on Long-term Mortality in Patients with ST-elevated Acute Myocardial Infarction(Symposium 9 (SY-09) (M) New Insight for Treatment of Ischemic Mitral Regurgitation,Special Program,The 72nd Annual Scientific Meeting
- 2 Dual Anti-platelet Therapy is Important to Prevent Thrombosis of Drug-eluting Stent Until Neointima Formation(Symposium 1 (SY-01) (IHD) Re-Evaluation of Drug Therapy in the DES Era,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circu
- No-reflow Phenomenon Is Associated With Legion Length in Patients With Acute Myocardial Infarction
- Prediction of Repeated Restenosis by Angioscopic Findings
- Is Amount of Thrombus At Culprit Lesion Associated With Microvascular Damage in Patients With Acute Myocardial Infarction?
- Sustained elevation of brain natriuretic peptide (BNP) concentrations in patients with left ventricular remodeling after myocardial infarction
- Smoking Status on Thrombus and Plaque in The Culprit Vessel in Patients with Acute Myocardial Infarction : Angioscopic Findings
- Advanced age increased the occurrence of heart failure in patients with acute myocardial infarction due to increased ischemic risk area
- Correlation Between Intima-Media Thickening of Carotid Arteries and Intra-Coronary Yellow Plaques
- Future Ischemic Events Can be Predicted by Angioscopic Evaluation of Yellow Plaques
- The relationship between yellow coronary plaques observed with an angioscopy and lipid profile in patients with coronary artery disease
- 3 Identification of Vulnerable Plaque by Coronary Angioscopy(Symposiums (SY3) (I) : Imaging Vulnerable Atherosclerotic Plaque : The Evolving of New Imaging Technique)(Special Program)
- Stent Patency At A Glance By "Coronary Plaque Map" System by Multidetector Row Computed Tomography (X-ray/CT/MRI/DSA 8 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Recovery of Microvasucular Circulation Improves LV Electrical Vulnerability and Ejection Fraction At 6 Month After AMI(Acute Myocardial Infarction, Clinical (Pathophysiology) 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Patency of the Infarct-Related Artery Modifies the Brain Natriuretic Peptide (BNP) Production After Myocardial Infarction(Neurohumoral Factors 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Quantitative Analysis of Coronary Vein In Patients With Low Left Ventricular Function by Multi-detector Row Computed Tomography(X-ray/CT/MRI/DSA 5 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Quantitative Analysis of Vessel and Remodeling by Multi-detector Row Computed Tomography Using "Plaque Map" System(X-ray/CT/MRI/DSA 3 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-323 The Efficacy of Intravascular Ultrasound (IVUS) for Percutaneous Coronary Intervention (PCI) in Acute Coronary Syndrome (ACS)(Intravascular Endoscopy/Intravascular Ultrasound 2 (I) : PJ54)(Poster Session (Japanese))
- PJ-221 Yellow Color Intensity of Plaques Is Associated With Their Vulnerability(Acute Coronary Syndrome, Basic/Clinical 4 (IHD) : PJ37)(Poster Session (Japanese))
- OJ-457 Impact of coronary vasospasm on acute coronary syndrome(Acute Coronary Syndrome, Basic/Clinical 5 (IHD) : OJ56)(Oral Presentation (Japanese))
- OJ-402 Strict control of cholesterol levels by statin use is significantly associated With Coronary plaques evaluated by angioscopy.(Intravascular Endoscopy/Intravascular Ultrasound 5 (I) : OJ49)(Oral Presentation (Japanese))
- OJ-161 The Reliability of Vulnerable Plaques Detected by Multi-Detector Row Spiral Computed Tomography in Patients of Acute Coronary Syndrome(X-ray/CT/MRI/DSA2 (I) : OJ19)(Oral Presentation (Japanese))
- OJ-320 Granulocyte Colony-Stimulating Factor Mediates Cardioprotection against Ischemia/Reperfusion Injury via Phosphatidylinositol-3-Kinase/Akt Pathway : Evaluation in Vitro Cardiomyocytes and in Vivo Canine Hearts(Acute myocardial infarction, basic-2 (I
- PE-556 Warfarin School : The Effectiveness of Patients Education for Warfarin Therapy(Preventive medicine/Epidemiology/Education-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-298 The Effect of Statin Treatment on the Regression of Yellow Plaque Detected by Angioscopy : Quantitative Analysis Using LCH Color Space(Atherosclerosis, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-200 Carotid Intima-media Thickness Reflects Coronary Artery Vulnerability(Atherosclerosis, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-004 Stabilization of Non-culprit Vulnerable Yellow Plaques after the Onset of Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-091 Quantitative Analysis of Vulnerable Plaque Color Using LCH Color Space(Intravascular endoscopy/Intravascular ultrasound-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-040 Analysis on Risk of Thrombosis at Coronary Plaque(Atherosclerosis, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Hyperlipidemia is a Risk Factor of Intra-Coronary Yellow Plaque Progression
- IS190 Fibrinogen and Fibrin D-dimer Levels in Chronic Atrial Flutter : Is There Excess in Intravascular Thrombogenesis?
- MDCT Coronary Angiography Using Low-Dose Contrast Media with Saline Chaser(X-ray/CT/MRI/DSA 1 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Detecting of Carotid Artery Plaque Characterization by Novel Analysis System, "Carotid Plaque Map" on MDCT(X-ray/CT/MRI/DSA 3 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Role of Plaque Rupture in the Development of Acute Coronary Syndrome Evaluated by the Coronary Angioscope
- 4 Plaque Stabilization and Regression by Lipid Lowering Therapy in Japanese Patients With Coronary Heart Disease(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Program,The 72nd Annual Scientific M
- Stabilization and Regression of Coronary Plaques Treated With Pitavastatin Proven by Angioscopy and Intravascular Ultrasound : The TOGETHAR Trial
- Formation of Intra-Coronary Yellow Plaque Is Associated with Deterioration of Nitric Oxide Bioavailability
- Myocardial Stiffening Is Not Due to Myocardial Hypertrophy but to Myocardial Fibrosis in Human Left Ventricular Hypertrophy
- Amount of Thrombus at Culprit Lesion of Acute Myocardial Infarction Is Dependent on Angioscoopically Determined Coronary Atherosclerosis
- Gradual Recovery of Thallium Uptake at the Infarct Segement in Patients with Infarct Artery Patency after Myocardial Infarction
- Coverage of Culprit Plaque by Stent and the Rate of Restenosis
- Troponin T and Coronary Plaque Morphology by Angioscopic Evaluation
- Frequency and Location of Yellow and Disrupted Coronary Plaques in Patients as Detected by Angioscopy
- Relationship Between Coronary Plaque Vulnerability and Serum n-3/n-6 Polyunsaturated Fatty Acid Ratio
- Anodal Capture May Prevent Cardiac Resynchronization Therapy from Working Effectively. A Case Report of Left Ventricular Lead Dislodgement
- Acute Changes in the Pacing Threshold After Lead Implantation
- Small Left Atrial Diameter Is a Predictor of Ectopy from Superior Vena Cava in Patients with Atrial Fibrillation
- Atrial Fibrillation Was Associated with Sleep-Disordered Breathing in Heart Failure Patients
- Response Actions for Appropriate Implantable Cardioverter Defibrillator Therapies: Analysis of Recent 3-Year-Follow-Up Data
- Left Atrial Appendage Flow Cycle Length Is an Important Predictor of Sinus Rhythm Maintenance after Catheter Ablation of Persistent or Long-Standing Persistent Atrial Fibrillation
- Adjustment Operations for Inappropriate Implantable Cardioverter Defibrillator Therapies: Analysis of 3-Year-Follow-Up Data
- Regression of Luminal Stenosis at the Site of Silent Plaque Disruption in the Era of Optimal Medical Therapy:– Low High-Density Lipoprotein Cholesterol Level Is a Potential Risk of Stenosis Progression –
- Association of Target Lesion Characteristics Evaluated by Coronary Computed Tomography Angiography and Plaque Debris Distal Embolization During Percutaneous Coronary Intervention
- Patients with more coronary yellow plaques have higher risk of stenosis progression within 7 months