Endothelial Progenitor Cells Predict Long-Term Prognosis in Patients With Stable Angina Treated With Percutaneous Coronary Intervention:– Five-Year Follow-up of the PROCREATION Study –

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概要

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• Background: The association between endothelial progenitor cells (EPCs) at the time of percutaneous coronary intervention (PCI) and the subsequent long-term clinical outcome remains undefined. To address this issue, a pre-specified analysis of the PROgenitor Cells role in Restenosis and progression of coronary ATherosclerosis after percutaneous coronary intervention (PROCREATION) study was done. Methods and Results: A total of 155 patients with stable angina treated with PCI had flow cytometry before PCI. Patients had a 5-year follow-up. Primary outcome was the composite of major adverse cardiac or cerebrovascular events (MACCE), that is, death, stroke, myocardial infarction, and revascularization. During follow-up, MACCE occurred in 65 of 155 patients (42%). There were no significant differences in clinical and angiographic variables between patients with or without MACCE, apart from a different extent of coronary atherosclerosis. The incidence of MACCE increased significantly over tertiles of CD34+/KDR+/CD45– cells and CD133+/KDR+/CD45– cells, with rates of 25%, 39%, and 69% (P=0.0001), and 26%, 44%, and 59% (P=0.003), respectively. On multivariate analysis it was estimated that the increase in CD34+/KDR+/CD45– cells was associated with a 35% higher risk for MACCE (hazard ratio [HR], 1.75; 95% confidence interval [CI]: 1.07–1.99; P=0.001), and the increase in CD133+/KDR+/CD45– cells was associated with a 25% higher risk for MACCE (HR, 1.35; 95% CI: 1.01–1.74; P=0.03). Conclusions: Assessment of subpopulations of circulating EPCs in patients with stable angina treated with PCI can improve characterization of long-term prognosis (ClinicalTrials.gov: NCT01575431).

著者

• Greco Cesare

  Department "Attilio Reale", Sapienza University

• Greco Cesare

  Department of Cardiology, Sapienza University

• Rosano Giuseppe

  Department of Cardiovascular Research, IRCCS San Raffaele Pisana

• Pelliccia Francesco

  Department "Attilio Reale", Sapienza University

• Gaudio Carlo

  Department "Attilio Reale", Sapienza University

• Pasceri Vincenzo

  Department of Cardiovascular Diseases, San Filippo Neri Hospital

• Pristipino Christian

  Department of Cardiovascular Diseases, San Filippo Neri Hospital

• Roncella Adriana

  Department of Cardiovascular Diseases, San Filippo Neri Hospital

• Speciale Giulio

  Department of Cardiovascular Diseases, San Filippo Neri Hospital

• Pannarale Giuseppe

  Department of Cardiology, Sapienza University

• Schiariti Michele

  Department of Cardiology, Sapienza University

• Pelliccia Francesco

  Department of Cardiology, Sapienza University

• Gaudio Carlo

  Department of Cardiology, Sapienza University

関連論文

• Endothelial Progenitor Cells Predict Long-Term Prognosis in Patients With Stable Angina Treated With Percutaneous Coronary Intervention:– Five-Year Follow-up of the PROCREATION Study –
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