Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers

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概要

• 論文の詳細を見る

• Nanocarrier-based cancer chemotherapeutics are thought to increase therapeutic efficiency and reduce the side effects of associated chemotherapeutic agents by altering the agents' pharmacokinetics and tissue distribution following intravenous administration. In spite of these favorable properties, nanocarrier-based cancer chemotherapeutics are not always effective because of their heterogeneous intratumoral localization. Homogeneous distribution of nanocarriers in a tumor would improve the efficacy of nanocarrier-based cancer chemotherapeutics. In this article, we describe and discuss some trials that attempt to manipulate the barriers in the tumor microenvironment that hinder extravasation through the tumor vasculature and penetration of nanocarriers in solid tumors. Alterations of the tumor microenvironment that relate directly to the intratumoral distribution of nanocarriers may be potential strategies to improve the delivery of nanocarrier-based cancer chemotherapeutics.

• 公益社団法人 日本薬学会の論文

著者

• Kiwada Hiroshi

  Department of Pharmacokinetics and Biopharmaceutics, Institute of Health Biosciences, The University of Tokushima

• Ishida Tatsuhiro

  Department of Pharmacokinetics and Biopharmaceutics, Institute of Health Biosciences, The University of Tokushima

関連論文

• Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers

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