Role of Nuclear Localization of PSMB1 in Transcriptional Activation

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概要

• 論文の詳細を見る

• The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.

著者

• YAMAUCHI Jun

  Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

• ISHIMI Yoshiko

  Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

• SEKIGUCHI Mariko

  Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

• SHIRAI Tomomi

  Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

• YAMADA Mami

  Section of Food and Nutrition Labeling, Department of Food Function and Labeling, National Institute of Health and Nutrition

関連論文

• Vitamin D Receptor Is Not Essential for Extracellular Signal-Related Kinase Phosphorylation by Vitamin D_3 in Human Caco-2/TC7 Cells
• Role of Nuclear Localization of PSMB1 in Transcriptional Activation

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