Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids

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概要

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• The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.

著者

• Aoki Reiji

  Functional Biomolecules Research Group, The Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

• Takayama Yoshiharu

  Functional Biomolecules Research Group, The Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

• SUZUKI Chise

  Functional Biomolecules Research Group, The Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

• AOKI-YOSHIDA Ayako

  Functional Biomolecules Research Group, The Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

• KAWASUMI Toshiyuki

  Faculty of Home Economics, Japan Women's University

• ICHIDA Kasumi

  Functional Biomolecules Research Group, The Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization

関連論文

• Protective effect of pyruvate against UVB-induced damage in HaCaT human keratinocytes(BIOCHEMICAL ENGINEERING)
• Prevention of UVB-Induced Production of the Inflammatory Mediator in Human Keratinocytes by Lactic Acid Derivatives Generated from Aromatic Amino Acids

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