Expression Pattern Implicates a Potential Role for LRF in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice
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概要
- 論文の詳細を見る
Luman/CREB3 recruitment factor (LRF or CREBRF) was identified as a regulator of Luman (or CREB3) that is involved in the unfolded protein response during endoplasmic reticulum stress. Luman is implicated in a multitude of functions ranging from viral infection and immunity to cancer. The biological function of LRF, however, is unknown. In this paper, we report that uteri of pregnant mice and embryos displayed enhanced LRF expression at all stages, and the expressed LRF was found to be localized specifically at implantation sites. On the other hand, uteri of mice induced for delayed implantation or pseudopregnant mice showed low levels of LRF expression, suggesting that LRF mediates uterine receptivity during implantation. Further, expression of LRF was found to be modulated by steroid hormones such as progesterone and estradiol. This study thereby identifies a potential role for LRF in the process of implantation in uteri and development of preimplantation embryos in mice.
- 日本繁殖生物学会の論文
著者
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LU Ray
Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada N1G 2W1
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WANG Aihua
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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YANG Yanzhou
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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JIN Yaping
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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MARTYN Amanda
Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada N1G 2W1
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LIN Pengfei
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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SONG Yujie
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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CHEN Fenglei
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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HU Linyong
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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CUI Chenchen
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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LI Xiao
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
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LI Qian
Key Open Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A University, Yangling Shaanxi 712100, P.R. China
関連論文
- Expression Pattern Implicates a Potential Role for LRF in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice
- Expression Pattern Implicates a Potential Role for Luman Recruitment Factor in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice