Synthesis and Biological Evaluation of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Potential Cytotoxic Agents

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概要

• 論文の詳細を見る

• A series of new 3-amino-5-sulfanyl-1,2,4-triazole and 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives have been synthesized and their cytotoxicities were evaluated on a panel of human cancer cell lines (BxPC-3, H1975, SKOV-3, A875, HCT116, etc.). The best one (compound 5m) exhibited activities with IC50 values ranging from 0.04 to 23.6 µ<span style="font-variant: small-caps;">M</span> against nine human cancer cell lines. Further biological evaluation indicated that DNA replication was blocked by treatment with compound 5m in HCT116 cells.

• 公益社団法人 日本薬学会の論文

著者

• Li Xiao

  State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany

• Yu Luo-Ting

  State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University

• Shi Yao-Jie

  State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University

• Song Xue-Jiao

  State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University

• Ye Ting-Hong

  State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University

• Xiong Ying

  State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University

• Li Xiao

  State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University

関連論文

• Two New Icetexane Diterpenoids from Salvia przewalskii
• Synthesis and Biological Evaluation of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Potential Cytotoxic Agents

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