2″,4″-O-Diacetylquercitrin, a Novel Advanced Glycation End-Product Formation and Aldose Reductase Inhibitor from Melastoma sanguineum
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概要
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A new flavonoid, 2,″4″-O-diacetylquercitrin (1), along with six known flavonoids (2–7) were isolated from the aerial parts of Melastoma sanguineum. The structure of the new flavonoid was established by extensive spectroscopic studies and chemical evidence. The inhibitory effects of isolated compounds (1–7) on advanced glycation end-products (AGEs) formation and rat lens aldose reductase (RLAR) in vitro were examined. Of the tested compounds, compound 1 was the strongest inhibitor of AGEs, with an IC50 of 11.46±0.44 µ<span style="font-variant: small-caps;">m</span>. In the RLAR assay, all tested compounds exhibited greater inhibitory effects on RLAR than that of a positive control, 3,3-tetramethyleneglutaric acid (IC50=28.8±1.5 µ<span style="font-variant: small-caps;">m</span>); compound 1 exhibited the strongest RLAR-inhibitory activity, with an IC50 of 0.077±0.003 µ<span style="font-variant: small-caps;">m</span>.
著者
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Kim Joo-hwan
Department Of Biology Inha University
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Kim Il
KM-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine
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Lee Ik-Soo
KM-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine
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Lee Yun
KM-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine
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Lee Youngseop
Constitutional Medicine & Diagnosis Research Group, Korea Institute of Oriental Medicine
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Kim Jin
KM-Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine
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Lee Youngseop
Constitutional Medicine & Diagnosis Research Group, Korea Institute of Oriental Medicine
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- 2″,4″-O-Diacetylquercitrin, a Novel Advanced Glycation End-Product Formation and Aldose Reductase Inhibitor from Melastoma sanguineum