Synthesis and Biological Evaluation of New Heteroaryl Carboxylic Acid Derivatives as Anti-inflammatory-Analgesic Agents

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概要

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• A series of nicotinic acid derivatives structurally related to niflumic acid and certain pyridazine-containing compounds have been synthesized and characterized by analytical and spectral data. All compounds were screened for their potential analgesic and anti-inflammatory activities. The compounds which displayed analgesic and anti-inflammatory activities were tested for ulcerogenicity and screened for in vivo inhibition of certain inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2). Compounds 1c, 2a, 2b, and 5a have shown potent analgesic and anti-inflammatory activities.

• 公益社団法人 日本薬学会の論文

著者

• Ahmed Eman

  Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University

• Khalil Nadia

  Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University

• Zaitone Sawsan

  Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University

• Abouzid Khaled

  Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University

関連論文

• Synthesis of New Nicotinic Acid Derivatives and Their Evaluation as Analgesic and Anti-inflammatory Agents
• Synthesis and Biological Evaluation of New Heteroaryl Carboxylic Acid Derivatives as Anti-inflammatory-Analgesic Agents

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