Synthesis of Novel Phosphorylated Guanidine Derivatives from Cyanamide and Their Anti-inflammatory Activity

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概要

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• A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a–l). The substituent in the guanidine function affected the potency of anti-inflammatory activity. The compounds having benzothiazole, fluorophenyl, and piperazinyl moieties enhanced the anti-inflammatory activity.

• 公益社団法人 日本薬学会の論文

著者

• Chamarthi Naga

  Department of Chemistry, Sri Venkateswara University

• Katla Venkata

  Department of Chemistry, Sri Venkateswara University

• Syed Rasheed

  Department of Chemistry, Sri Venkateswara University

• Kuruva Chandra

  Department of Chemistry, Sri Venkateswara University

• Kuntrapakam Hema

  Aptus BioSciences Private Limited

関連論文

• Synthesis of Novel Phosphorylated Guanidine Derivatives from Cyanamide and Their Anti-inflammatory Activity

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