Effect of Psychotropics on the NAD (Nicotinamide Adenine Dinucleotide) Metabolism in the Mouse
スポンサーリンク
概要
- 論文の詳細を見る
The effects of the psychotropics on the NAD metabolism of the mouse brain and liver were investigated mainly by measuring the transient increase of NAD levels which occurred in response to nicotinamide injection, and the mechanisms of their actions were analysed. Thus the following results were obtained.<BR>1) The psychotropics which depress the central nervous system, such as serpasil, chlorpromazine, perphenazine, haloperidol, tetrabenazine, levomepromazine, chlorprothixene, methopromazine, and phenobarbital, caused marked changes in the NAD response of both brain and liver. These drugs prevented the return of the NAD level elevated by nicotinamide injection to normal at the end of 24 hours, whereas the NAD level usually returned to normal within 24 hours after nicotinamide administration in the normal mouse. Antidepressants, such as imipramine and amitryptiline, had no effect on the NAD response of brain and liver.<BR>2) The effects of the former group of the psychotropics seemed to be connected with their temperature-lowering effects. When hypothermia was prevented in high room temperature, the changes of NAD response by these drugs disappeared throughly or were lessened.<BR>3) The large doses of hormones and biogenic amines (and related compounds) had little influences upon the NAD response. Even if these drugs were administered with the psychotropics, the effects of the latters were not inhibited. Thus it seems improbable that the changes in NAD response by psychotropics occur secondarily through the changes of the hormonal environment and catecholamine levels.<BR>4) All the psychotropics seemed to decrease the endogenous NAD of the brain. Above all, serpasil had the most striking effect and decreased the NAD level of the brain to 70 per cent of the normal 24 hours after its injection.