On the Bromine Compound Contained Physiologically in Human Cerebrospinal Fluid

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In the course of investigation on bromide poisoning, it was found that, inaddition to exogenous bromide, a bromine containing substance existed physiologically in cerebrospinal fluid. This observation was made possible only by a newly developed method which prevents volatile compounds f rom any loss due to decomposition.<BR>The average concentration of total bromine in CSF of 80 normal persons was found to be 7.6 milligrams per one hundred milliliters, with a decreasing trend notedin those of middle age on.<BR>The greater portion of CSF bromine exited in the form of an organic bromine compound. This compound was isolated by means of silicic column chromatography from a large amount of cerebrospinal fluid pooled in ethanol, and was identified as 2-octyl-γ-bromoacetoacetate. Subsequently, this organic bromine compound, and its 50 derivatives, were synthetized and tested in an effort to determine their effect on sleep behavior, and the results, obtained to date, indicate that these compounds caused an increase of slow wave sleep and had no discernible effect on occurrence of paradoxical sleep. In these experiments, 2-octyl-γ-bromoacetoacetate showed the highest activity to the cat.
Japan Society of Clinical Chemistryの論文