A New Automated Determination of Serum Apolipoprotein A-I by Immunoturbidimetry and its Clinical Applications

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It is well known that serum apolipoprotein A-I (apo A-I) is an important component of high density lipoproteins (HDL) and also plays some important physiologic roles. Although several technics for quantitating apo A-I have been reported, they are complicated technically and are not feasible for automation.<BR>In this paper, we describe a new immunoturbidimetric assay for the determination of apo A-I by automated analysers.High precision and good correlation with the single radial immunodiffusion (SRID) method were obtained. The normal value of Apo A-I levels in male (n=82) and in female (n=82) were 122±24 mg/di (mean±S.D.) and 124±24 mg/di respectively. Apo A-I levels in patients with hepatitis, nephritisand old myocardial infarction were significantly decreased as compared with those of normals. <BR>This method is useful and widely acceptable for the prediction of the risk of coronary heart disease in addition to HDL-cholesterol determination.
Japan Society of Clinical Chemistryの論文