α<SUB>2</SUB>-Macroglobulin Levels in Relation to Glucose and Lipoprotein Metabolism

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概要

• 論文の詳細を見る

• α<SUB>2</SUB>-Macroglobulin (α<SUB>2</SUB>-MG), a plasma protease inhibitor, has been proposed to be involved in glucose and lipoprotein metabolism. In this study, the relationship between α<SUB>2</SUB>-MG and glucose or specific lipoproteins was examined. After glucose loading, α<SUB>2</SUB>-MG levels were significantly lowered while glucose levels increased. After fat loading, α<SUB>2</SUB>-MG levels were significantly elevated as well as triglyceride and remnantlike particle cholesterol (RLP-C) levels. α<SUB>2</SUB>-MG values of diabetic patients were significantly higher than those of healthy subjects (222.3± 20.1 <I>vs</I>. 175.4±7.6mg/dl p<0.05) but decreased significantly from 220.9±17.1 to 209.4±16.6mg/dl following strict glycemic control. These data suggest that α<SUB>2</SUB>-MG levels are related to the state of glucose and lipoprotein metabolism and that α<SUB>2</SUB>-MG may serve as a marker of diabetes mellitus.

• Japan Society of Clinical Chemistryの論文

著者

• 吉成 仁

  岩手医科大学第一内科

• 吉成 仁

  岩手医科大学第1内科

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• α2-Macroglobulin Levels in Relation to Glucose and Lipoprotein Metabolism

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