Determination of Drugs Using Natural/Synthetic Receptors

概要

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<I>In-vitro</I> tests using isolated receptors for the binding of ligands, that is receptor assays, are powerful tools for determining of physiological/ pharmacological activities of biologically active substances. In this article, receptor assays for benzodiazepine drugs are described, including radioreceptor assays and non-isotopic receptor assays. Competitive binding assays using synthetic receptors are also described as a newly developed technique, in which the synthetic receptors are prepared by a molecular imprinting technique. Typical data obtained by these three receptor assays are shown and the characteristics and usefulness of each assay are reviewed.
Japan Society of Clinical Chemistryの論文