Serum Alkaline Phosphatase:Age and Sex Differences of Values in Adolescents and its Isoenzyme Characteristics

概要

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Serum alkaline phosphatase levels in normal adolescents were studied in 247 males and 237 females subdivided by sex, age and blood type. lsoenzyme characteristics in some cases were also studied.<BR>Alkaline phosphatase activity was measured by the kinetic method for sera from 10, 13, 16 and 19 years old men and women. No statisticallsyi gnificant influence of blood type on enzyme activity was observed in all cases. Alkaline phosphatase level at age 19 is essentially equal to that of adults and shows no significant difference between males and females. The activities in both sexes at age 10, 13 and 16 are in apparent higher level, and the difference in the activitiesb etween males and females are observed at these ages. From the study of isoenzyme characteristics, it is considered that the high level of alkaline phosphatase in the serum from adolescent males and females is due to the high bone phosphatase seen during growth.<BR>The variations in those normal levels and isoenzyme characteristics are of clear importance in assessing data from individual adolescent patients, for example, in comparison to adolescent with obesty.
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