Effects of 5-FU and a combination of tegafur and uracil (UFT) on nucleotide metabolism and cell cycle in L1210 ascites tumor

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The effects of 5-FU and UFT (a combination of tegafur and uracil,1: 4) on nucleotide metabolism and cell cycle were investigated in L1210 ascites tumor.5-FU (13mg/kg)and equimolar UFT(FT: 20mg/kg)were orally administered on day 3 after tumor inoculation. One and 6hr after administration of 5-FU, the intracellular dTTP pool was decreased to half the control level, but increased to 1.5 fold of the control level at 12hr. In contrast, the dTTP pool was decreased until 24hr after administration of UFT. The intracellular dCTP pool was decreased and dATP pool was increased after administration of 5-FU and UFT, but the changes in both nucleotides were greater and more prolonged after UFT administration. Cells in G0-G1 phase were decreased from 39% to about 20%, and cells in S phase were increased from 47% to about 70% after administration of both drugs, but the maximum changes were observed at 12hr after 5-FU and at 24hr after UFT administration.