The relationship between ultrasonograhically diagnosed fatty liver disease, metabolic syndrome and insulin resintance in adults

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In this study, the relationship between fatty liver disease (Group FL, 94 subjects) diagnosed by ultrasonography, metabolic syndrome and insulin resistance (IR) was assessed and compared with the data of a normal liver group (Group N, 319 subjects). In a comparison of Group FL to Group N, statistically significant values were obtained for fasting plasma glucose level (p<0.0001), triglycerids (p<0.0001), HDL-cholesterol (p<0.0001), LDL-cholesterol (p<0.0001) and diastolic blood presure (p=0.018) in men, and triglycerids (p<0.0001) and HDL-cholesterol (p<0.05) in women. The average value of the homeostasis model assessment insulin resistance index (HOMA-IR) was statistically higher in Group FL than in Group N in men (2.1±1.0 vs 1.2±0.1, p<0.0001). Also, in women, the average value of HOMA-IR was statistically higher in Group FL than in Group N (1.6±0.9 vs 1.1±0.5, p=0.008). In men, the percentage of IR was statistically higher in Group FL than in Group N (30% vs 4%, p<0.0001) and in women, the value of IR was statistically higher in Group FL than in Group N (18% vs 1%, p=0.01). These findings suggest that fatty liver disease diagnosed by ultrasonography may manifest insulin resistance and be closely related to metabolic syndrome.
一般社団法人日本消化器がん検診学会の論文