Characterization of the Erythrocyte Membranes from Children Patients Infected with Mycoplasma Pneumoniae
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概要
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The erythrocytes of children patients infected with <I>Mycoplasma pneumoniae</I> are very hemolytic and abnormally shaped. It appears that the toxic substances of M. pneumoniae or <I>M. pneumoniae</I> itself effected on the erythrocyte membrane. The activity of Ca++ -ATPases and the contents of total sialic acid of the erythrocyte membrane (ghost) from patients were decreased by about 50%. And also the level of intracellular ATP was declined. In accordance with the recovery from illness, the activity of Ca++ -ATPase, the content of sialic acid and the level of ATP were increased to the level of the control. Whereas in the cases of mixed infection with <I>Staphyro coccus aureus, Streptococcus pyogenes</I> and RS virus, the activity of Ca++ -ATPases and the contents of total sialic acid had been recovered to the level of the control within a week or so, the ATP contents were less than that of the erythrocytes from patients infected with M. pneumoniae alone.<BR>There must be different effects of their toxic substances between <I>M. pneumoniae</I>, bacteria and virus on the erythrocyte membrane.
- Japan Society of Clinical Chemistryの論文