Polynucleotide Ligase from Rat Liver after Partial Hepatectomy and Hepatoma

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概要

• 論文の詳細を見る

• Polynucleotide ligase, which catalyzes covalent joining of two segments of an interrupted strand in a DNA duplex, was studied with normal rat liver, regenerating rat liver and hepatoma induced by N-2-fluorenylacetamide. The activity is located in both nuclei and soluble fractions. Its optimal pH was 8.0. The enzyme requires ATP as a cofactor. Its activity was completely dependent on the presence of Mg<SUP>2+</SUP>. The activities of these enzymes in regenerating rat liver were 4 times higher, in both fractions, than those in normal rat livers, whereas in hepatoma they were about 5 times higher in soluble fraction, and about 3 times higher in nuclear fraction than those in normal rat liver.

• Japan Society of Clinical Chemistryの論文

著者

• 伊東 信行

  奈良医科大学第一病理

• 塚田 欣司

  富山大学薬学部

関連論文

• Polynucleotide Ligase from Rat Liver after Partial Hepatectomy and Hepatoma
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