Pharmacological Studies of CG-120 (Uralyt-U ) on Urinary pH and Urinary Uric acid Excretion (No. 2)

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The pharmacological studies of CG-120 (Uralyt-U) were investigated, in rats. The rise of urinary pH which was indicated by both CG-120 and sodium bicarbonate (NaHCO3) paralleled the increase of urinary HCO3- concentration. This result seemed that the alkalogenic effects of CG-120 and NaHCO3 on urine were caused by the increase of urinary HCO3- concentration. In addition, the sustained times of both agents were approximately the same, but in comparison with NaHCO3, CG-120 did not show the acute rise of urinary pH and the sudden increase of urinary HCO3- concentration. This observation suggested that CG-120 may be more safely for the organism as compared with NaHCO3. On the other hand, the rise of urinary pH and the increase of urinary uric acid excretion were observed when CG-120 was respectively administrated together with furosemide, allopurinol and benzbromarone. These results suggest that CG-120 may be useful agent for the subsidiary therapy of hyperuricemias.