Rapidly Progressive Respiratory Failure in Mixed Connective Tissue Disease: Report of an Autopsy Case
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概要
- 論文の詳細を見る
A 64-year-old woman presented with exertional dyspnea. The case was diagnosed as mixed connective tissue disease (MCTD) due to presence of swollen fingers, Raynaud's phenomenon, muscle weakness, positive anti-U1RNP antibody, pericarditis and interstitial pneumonia. Although the histology from a transbronchial lung biopsy (TBLB) indicated organizing pneumonia, corticosteroid therapy was postponed for two months at the patient's request. She died 8 weeks later from acute progressive interstitial pneumonia in spite of the administration of intravenous cyclophosphamide combined with prednisolone. The autopsy revealed exudative and organizing diffuse alveolar damage (DAD). Previous reports have shown that DAD is an extremely rare pulmonary complication in MCTD. This report presents a case of MCTD with acute respiratory failure. This case thus suggests that this therapy should be administered as soon as possible.
- 社団法人 日本内科学会の論文
著者
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Moriguchi Masato
Division Of Integrated Medicine I Omiya Medical Center Jichi Medical School
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WATANABE Yasutaka
Division of Respiratory Medicine, Jichi Medical University, Saitama Medical Center
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NOKUBI Mitsuhiro
Division of Pathology, Jichi Medical University, Saitama Medical Center
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KOYAMA Shinichiro
Division of Respiratory Medicine, Jichi Medical University, Saitama Medical Center
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Kawabata Yoshinori
Division Of Pathology The Research Institute Of Tuberculosis
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Miwa Chihiro
Division of Pulmonary Medicine, Saitama Medical Center, Jichi Medical University, Japan
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Terai Chihiro
Division of Reumatology, Jichi Medical University, Saitama Medical Center, Japan
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Shiraishi Mamoru
Division of Pulmonary Medicine, Jichi Medical University, Saitama Medical Center, Japan
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Nomura Motoko
Division of Pulmonary Medicine, Jichi Medical University, Saitama Medical Center, Japan
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Watanabe Yasutaka
Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Saitama Medical Center, Jichi Medical University
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Watanabe Yasutaka
Division of Pulmonary Medicine, Jichi Medical University, Saitama Medical Center, Japan
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Miwa Chihiro
Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Saitama Medical Center, Jichi Medical University
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Miwa Chihiro
Division of Pulmonary Medicine, Jichi Medical University, Saitama Medical Center, Japan
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Koyama Shinichiro
Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Saitama Medical Center, Jichi Medical University
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Koyama Shinichiro
Division of Pulmonary Medicine, Jichi Medical University, Saitama Medical Center, Japan
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