Platinum-Catalyzed Direct Amination of Allylic Alcohols
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概要
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Transition metal-catalyzed amination of allylic compounds via a π-allylmetal intermediate is a powerful and useful method for synthesizing allylamines. Direct catalytic substitution of allylic alcohols with amines, which forms water as the sole coproduct, has recently attracted attention in terms of its environmental and economical advantages. Here, we describe the development of a direct catalytic amination of both aryl- and alkyl-substituted allylic alcohols with various amines including the smallest nitrogen nucleophile ammonia using Pt-Xantphos and Pt-DPEphos catalyst systems, which allow the selective synthesis of various monoallylamines including the biologically active compounds naftifine and flunarizine, in good to high yield without requiring any activator.
著者
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Mashima Kazushi
Department Of Chemistry Graduate School Of Engineering Science Osaka University
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Ohshima Takashi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Ohshima Takashi
Graduate School of Pharmaceutical Sciences, Kyushu University
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