THE EFFECTS AND COMPLICATIONS INDUCED BY NIFEDIPINE ADMINISTRATION DURING NITROUSOXIDE-OXYGEN-HALOTHANE ANESTHESIA

概要

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The results of 10mg nifedipine (Adalat) administration sub-lingually during nitrousoxide-oxygen-halothane (GOP) anesthesia were as follows: 1) Hypotensive effects of nifedipine were only seen in hypertensive patients. Nieedipine did not produce any effect on the normotensive group. 2) There was no difference between the rates of systolic and diastolic blood pressure decreases. 3) The hypotensive effects of nifedipine started within 5 minuted after administration, and blood pressure decreased by degrees for 15 minutes. Nifedipine's total effect lasted for 40 minutes. 4) The appearance of the hypotensive effect of nifedipine depended on blood pressure immediately before its administration rather than on the patient's causal blood pressure condition. 5) There was on significant change in pulse rate. Case report: we reported a case of sudden drug-related onset of drop in blood pressure, as well as arrhythmia by nifedipine administration.
学校法人昭和大学・昭和医学会の論文