Enhancement of the Immunostimulatory Activity of 1,25-Dihydroxyvitamin D3-Differentiated HL60 Cells with an Arabinoxylan from Wheat Bran

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概要

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• We found that a wheat bran arabinoxylan (WBA) activates the phagocytosis of 1,25-dihydroxyvitamin D3-differentiated HL60 cells; however, its mechanism was unknown. Hence, we investigated the molecular mechanism involved in the WBA-induced increase of immunostimulating activity using inhibitors. The results indicated that the WBA-induced increases in phagocytic activity and IL-1β production were inhibited by cathepsin B and caspase-1 inhibitor. Moreover, IL-1β production was inhibited by a phagocytosis inhibitor.

著者

• Monobe Manami

  Naro Institute Of Vegetable And Tea Science (nivts)

• KATAYANAGI Yuki

  Nisshin Pharma Inc.

• HIRAMOTO Shigeru

  Nisshin Pharma Inc.

• MAEDA-YAMAMOTO Mari

  NARO Institute of Vegetable and Tea Science (NIVTS)

関連論文

• Enhancement of the Immunostimulatory Activity of 1,25-Dihydroxyvitamin D3-Differentiated HL60 Cells with an Arabinoxylan from Wheat Bran
• Enhancement of the Immunostimulatory Activity of 1,25-Dihydroxyvitamin D3-Differentiated HL60 Cells with an Arabinoxylan from Wheat Bran

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