Spontaneous Renal Tumors Suspected of Being Familial in Sprague-Dawley Rats
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概要
- 論文の詳細を見る
Spontaneous renal tubule tumors (RTTs), with a distinctive morphological phenotype, were present in three Sprague-Dawley rats, 1 male and 2 females, out a total of 120 animals of each sex from untreated and placebo control groups in a 2-year carcinogenicity study. One female had one carcinoma, adenoma and hyperplasia, and the other female had five adenomas and many hyperplastic lesions; the male case had one carcinoma. From these cases, a biological continuum of hyperplasia, adenoma and carcinoma could be recognized. The tumors were present in the renal cortex and appeared as solid lobulated growths with occasional central necrosis. The lobules were divided by a small amount of fibrovascular tissue. Occasionally the larger tumors contained a cystic area. Tumor cells appeared distinctive and exhibited variable amounts of eosinophilic/amphophilic and vacuolated cytoplasm. Nuclei were round to oval with a prominent nucleolus. Mitotic figures were uncommon, and no distant metastasis was noted. The tumors were seen as multiple and bilateral lesions in two animals and had no apparent relationship to chronic progressive nephropathy (CPN). Foci of tubule hyperplasia were also noted to contain the same type of cellular morphology. The morphological and biological features of these 3 cases resembled the amphophilic-vacuolar (AV) variant of RTT that has been posited to be of familial origin. This is a report of spontaneous familial renal tumors in Sprague-Dawley rats from Japan.
著者
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Seely John
Experimental Pathology Laboratories Inc.
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Saito Tsubasa
Pathology Department, Gotemba Laboratories, Bozo Research Center Inc.
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Nakazawa Tomomi
Pathology Division, Gotemba Laboratories, BOZO Research Center Inc.
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Tamura Kazutoshi
Pathology Department Gotemba Laboratory Bozo Research Center Inc.
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Shimoyama Natsumi
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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Seely John
Experimental Pathology Laboratories Inc., Research Triangle Park, North Carolina, USA
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Suzuki Isamu
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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Saito Tsubasa
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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Tamura Kazutoshi
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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Kudo Kayoko
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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Hoshiya Toru
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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Nakazawa Tomomi
Pathology Division, Gotemba Laboratory, Bozo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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SUZUKI Isamu
Pathology Division, Gotemba Laboratories, BOZO Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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KUDO Kayoko
Pathology Division, Gotemba Laboratories, BOZO Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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HOSHIYA Toru
Pathology Division, Gotemba Laboratories, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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