Splenic Hemangiosarcoma in a Young Sprague-Dawley Rat
スポンサーリンク
概要
- 論文の詳細を見る
The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that showed invasive growth without encapsulation and were arranged solidly but partially in whorls or faint alveolar patterns with vascular-like spaces containing small clefts or erythrocytes in the tumor mass. Immunohistochemical analysis revealed that most of the tumor cells were strongly positive for vimentin, von Willebrand factor (vWF) and CD34 but negative for podoplanin. In addition, electron microscopic examination revealed the presence of Weibel-Palade bodies in the cytoplasm of the tumor cells. Based on these findings, this case was diagnosed as a hemangiosarcoma. The splenic masses were larger than the hepatic ones, with tumor cells mainly observed at periportal regions with tumor embolism in the liver, suggesting that primary hemangiosarcoma initially developed in the spleen before metastasizing.
著者
-
Oishi Yuji
Drug Safety Research Laboratories, Astellas Pharma Inc.
-
Takeuchi Ayano
Drug Safety Research Laboratories Astellas Pharma Inc.
-
Kajikawa Satoru
Drug Safety Res. Labs. Astellas Pharma Inc.
-
Ono Mihoko
Drug Safety Research Laboratories Astellas Pharma Inc.
-
Murakami Yuichi
Drug Safety Research Laboratories Astellas Pharma Inc.
-
Shiraki Katsuhisa
Drug Safety Research Laboratories Astellas Pharma Inc.
-
Matsumoto Masahiro
Drug Safety Research Laboratories Astellas Pharma Inc.
-
Oishi Yuji
Drug Safety Research Laboratories, Astellas Pharma Inc., 1-6 Kashima 2-chome, Yodogawa-ku, Osaka 532-8514, Japan
-
Murakami Yuichi
Drug Safety Research Laboratories, Astellas Pharma Inc., 1-6 Kashima 2-chome, Yodogawa-ku, Osaka 532-8514, Japan
-
Shiraki Katsuhisa
Drug Safety Research Laboratories, Astellas Pharma Inc., 1-6 Kashima 2-chome, Yodogawa-ku, Osaka 532-8514, Japan
-
Matsumoto Masahiro
Drug Safety Research Laboratories, Astellas Pharma Inc., 1-6 Kashima 2-chome, Yodogawa-ku, Osaka 532-8514, Japan
-
OISHI Yuji
Drug Safety Research Laboratories
関連論文
- テオフィリンを反復投与したF344ラットにおける顎下腺の遺伝子発現の変化
- Changes in Salivary Gene Expression in F344 Rats Exposed to Theophylline
- Gene expression changes induced by theophylline in the salivary glands of rats(Proceedings of the 32nd Annual Meeting)
- Nitrofurazone-induced changes in the rat liver(Proceedings of the 32nd Annual Meeting)
- Myocardial necrosis related to hydrochlorothiazide-induced hypokalemia in cynomolgus monkeys
- A Case of Spontaneous Malignant Hibernoma in a Crl:CD(SD)IGS Rat
- Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
- Development of neurological examination in beagle dogs(Proceedings of the 32nd Annual Meeting)
- Spontaneously Occurring Subcutaneous Tissue Sarcoma in a Sprague-Dawley Rat
- A Case of Spontaneous Malignant Hibernoma in a Crl:CD(SD)IGS Rat
- Splenic Hemangiosarcoma in a Young Sprague-Dawley Rat
- Inhibitory potency of tacrolimus ointment on skin tumor induction in a mouse model of an initiation-promotion skin tumor