One Pot Synthesis and Biological Activity Evaluation of Novel Schiff Bases Derived from 2-Hydrazinyl-1,3,4-thiadiazole

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概要

• 論文の詳細を見る

• Considering the structural features of a group of known potent inhibitors of human platelet aggregation containing hydrazone structural backbone, a series of novel hydrazone derivatives of 2-hydrazinyl-1,3,4-thiadiazole were synthesized using a one-pot process and tested for their inhibitory activity against platelet aggregation induced by arachidonic acid and ADP. Among the derivatives, compounds 3l, 3o and 3p exhibited the highest antiplatelet aggregation activity. The derivatives were also screened for their potential antimycobacterial activity and compounds 3g, 3k, 3p and 3q were among the most active compounds.

著者

• Kobarfard Farzad

  Department Of Medicinal Chemistry School Of Pharmacy Shaheed Beheshti University Of Medical Sciences

• Sardari Soroush

  Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute

• Haj Mohammad

  Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences

• Mashayekhi Vida

  Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences

• Esfahani Zadeh

  Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences

• Azerang Parisa

  Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute

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