Cerebral blood flow during pulsatile perfusion cooling

概要

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Postoperative brain damage in profound hypothermia have been reported extensively, and attributed to the disturbance of resional cerebral perfusion during hypothermia as one of the casations. In this experiment, the resional cerebral blood flow (CBF) of mongrel dog during the perfusion cooling with extracorporeal circulation (ECC) was measured by hydrogen gas clearance method. The mongrel dogs were cooled by pulsatile and nonpulsatile perfusion (pulsatile and nonpulsatile group). Both groups were cooled to an esophageal temperature of 20°C with the same perfusion rate (150ml/min/kg). In the pulsatile group, CBF under normothermic ECC scarcely decreased compared with physiological CBF before ECC. CBF under hypothermic ECC decreased compared with CBF under normothermic ECC in the both groups, but there was significant difference between two groups.
一般社団法人日本人工臓器学会の論文