EFFECT OF FIBRIL LENGTH ON HEALING OF EXPANDED POLYTETRAFLUOROETHYLENE (EPTFE) VASCULAR GRAFTS

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Two-mm internal diameter EPTFE grafts with fibril lengths of 15, 30, 60 and 90μm, the outer wall of which has the ridge structure similar to that of Technograft®, were prepared, and these graft segments of 2cm in length were placed end-to-end in the carotid arteries of normal male rabbits (n=48). Eight weeks after the implantation the grafts were retrieved and examined for degree of endothelial coverage, pseudointimal thickening and transmural tissue ingrowth. Luminal endothelial coverage, which exclusively originated from each anastomosis, was significantly promoted in the grafts of 30μm or longer compared with those of 15μm fibril length. We suggest that the rapid endothelialization is a result of a stable thrombotic coverage of the luminal surface of the EPTFE graft, followed by rapid transmural healing attributable to the longer fibril length. No complications, e.g. perigraft hematoma or seroma formation and decreasing patency rate, were found with increasing fibril length.
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