Therapeutical experiments of immunoabsorption plasmapheresis on myasthenia gravis and guillain-barre syndrome

概要

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Although plasmaexchange was reported to be partly effective for systemic neurological disease, its clinical usefulness was limited because of consuming a large amount of fresh frozen plasma and losing important plasma substances. To solve above prob-lems, immunoabsorption plasmapheresis, which does not require frozen plasma and reduced unnecessary removal of plasma substances, was tried. After applying immunoabsorption plasmapheresis to five myasthenia gravis and four Guillain-Barré syndrome patients, all patients were improved in the clinical symptomes within 2 weeks and amount of steroid and immunosuppressive agents could be reduced. Although, these therapy removed specific substances of the disease, there are no consistent pattern between symptomes and blood concentration of this substances. These results indicate that immunoabsorption plasmapheresis is clinicaly effective in neurological disease therapy and this method should be applied for severe myasthenia gravis patients and Guillain-Barré syndrome patients in acute phase after careful considerations of patients conditions.
一般社団法人日本人工臓器学会の論文