COMBINED BLOOD PURIFICATION THERAPY OF CONTINOUS ARTERO-VENOUS HEMOFILTRATION WITH HEMODIALYSIS FOR WEARABLE ARTIFICIAL KIDNEY

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Four stable patients undergoing maintenance hemodialysis at Shinseikai Daiichi hospital and kawashima hospital were studied. A 4-hours hemodialysis was followed by 6-day hemofiltration was performed. Heparin was continuously infused at the rate of 500 units/hour. Three liter replacement solution was infused at the venous side, and 5 liters of ultrafiltrate was obtained daily. Hemofiltration system including heparin infusion pump, filter and circuit weighed 1.2kg. Patients wearing the entire unit could move about freely. The blood pressure of patients remained stable and hypotension episodes didn't occur during CAVH. No changes in hemoglobin and hematcrit level were observed in any patients. BUN levels were 25.6±15.7mg/dl and 93.6±9.8 mg/dl, immediately after HD and 6-day later, respectively. Creatinine level was 4.16±2.20mg/dl im-mediately after HD and reached to 10.86±0.58mg/dl. 6 day later. PH was 7.464 im-mediately after HD reached to 7.387 6 day later. Base excess was 3.18mEq/L im-mediately after HD and reached 4.16.mEq/L at 6 day later, HCO3 was changed from 25.O4±3.52mEq/L immediately after HD and reached to 19.04±2.0mEq/L, at 6 day later. Serum calcium level varied from 4.0-5.5mEq/L. Serum phosphate increased to more than 6.0mg/dl in one patient. Serum β2-microglobulin level decreased during 1-2 week CAVH.
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