HPLC ANALYSIS OF LYMPHOCYTE BLASTOGENESIS PROMOTING FACTORS IN HAEMO-DIALYSATE OF PATIENTS WITH CHRONIC RENAL FAILURE

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概要

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• Fracdonation and purification of lymphocyte blastogenesis Fomoting factors extracted from haemodialysate of patients with chronic renal failure were carried out by high pefformance liquid chromatogaphy techniques. 1) The activity was eluated at capacity ratio (k') ranging from 2.08 to 2.45 (FLA and B). In this fraction, a major peak with an UV absorption maximum of 242nm and a few minor peaks were observed. 2) The established pharmacological agents were not eluated within Frs. A and B. Among these compounds, creatinine and hippuric acid were identified in the haemodialysates at k's of 0.85 and 7.11, respectively. 3) Both Frs. A and B showed the promoting activity in a dose-dependent manner. 4) A significant difference between Fr. B negative and positive haemodialysates was observed (p<0.002). As a result, these data suggested that factors included in hemodialysate would exhibit the promoting effect on lymphocyte blastogenesis.

• 一般社団法人 日本人工臓器学会の論文

著者

• 平野 俊彦

  Tokyo College of Pharmacy

• 岡 希太郎

  Tokyo College of Pharmacy

• 小崎 正巳

  Dep of organ transplantation, Hachiouji Medical Center of Tokyo Medical College

• 玉置 透

  Dep of organ transplantation, Hachiouji Medical Center of Tokyo Medical College

• 長浦 博

  Dep of organ transplantation, Hachiouji Medical Center of Tokyo Medical College

関連論文

• Structural and Conformational Studies of [Ile^7] and [Leu^7]Surfactins from Bacillus subtilis natto
• SATISFACTORY SEPARATION AND MS-MS SPECTROMETRY OF SIX SURFACTINS ISOLATED FROM BACILLUS SUBTILIS NATTO
• HPLC ANALYSIS OF LYMPHOCYTE BLASTOGENESIS PROMOTING FACTORS IN HAEMO-DIALYSATE OF PATIENTS WITH CHRONIC RENAL FAILURE

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